Anastrozole – a drug that inhibits the formation of estrogen. Active component – the same substance. This is a non-steroidal remedy. It is active against estragon-dependent (hormone-dependent) tumors in postmenopausal women. It is used in the treatment of advanced breast cancer and in the early stages in the postmenopausal period. Anastrazole is not taken during pregnancy. It is also contraindicated during menopause. Anastrazole is available on prescription. Details about the rules of administration of the drug and features of its medicinal effect are described in the full instructions.
For the first time the drug appeared on the market in 1995. First means are used exclusively for medical purposes. Anastrozole is used in the treatment of various tumors. Today in medicine, the drug is not widely used. Mostly anastrozolol is used by bodybuilders.
- It avoids gynecomastia
- Eliminates fluid retention, edema
- It eliminates the effects of receiving very potent steroids
Just 1 mg 80% reduction in blood estradiol. It is also observed:
- Blocking estrogen levels
- Reduced flavoring
- The powerful inhibitory effect
After about two hours there is the maximum concentration of Anastrozole. Therefore, the substance is incredibly fast helps athletes who are prone to the emergence of flavoring.
Anastrozole is a highly selective non-steroidal aromatase inhibitor – an enzyme with which in postmenopausal women, androstenedione in peripheral tissues is converted into estrone and then into estradiol. Reducing circulating concentrations of estradiol, as it turned out, has a positive effect on women with breast cancer. In postmenopausal women, anastrozole in a daily dose of 1 mg causes a decrease in the concentration of estradiol by 80%. Anastrozole does not have progestogenic, androgenic or estrogenic activity.
Regular intake of daily doses of anastrozole up to 10 mg does not affect the secretion of cortisol or aldosterone, therefore, its administration does not require the substitution administration of corticosteroids. Absorption of anastrozole is rapid, the maximum plasma concentration is reached within two hours after ingestion (on an empty stomach). Food slightly reduces the rate of absorption, but not its degree, and does not lead to a clinically significant effect on the equilibrium concentration of anastrozole in plasma when taken once daily intake of anastrozole. After seven days of taking the drug, approximately 90-95% of the equilibrium concentration of anastrozole in the blood plasma is reached. Information about the dependence of the pharmacokinetic parameters of anastrozole on time or dose no.
The pharmacokinetics of anastrozole does not depend on the age of postmenopausal women. Communication with plasma proteins – 40%. Anastrozole is eliminated slowly, the half-life from plasma is 40-50 hours. Extensively metabolized in postmenopausal women. Less than 10% of the dose taken is excreted by the kidneys unchanged within 72 hours after taking the drug. Anastrozole metabolism occurs through the stages of N-dealkylation, hydroxylation and glucuronidation. Triazole, the main metabolite of anastrozole in plasma, does not inhibit aromatase. Metabolites are excreted mainly by the kidneys. Anastrozole clearance after oral administration in case of liver cirrhosis or impaired renal function does not change.
We do not advise beginners to take anastrozole. The tool is applied only after prolonged steroid course in high dosages. The tablets are:
- If there are side effects of steroids
- For prevention
When signs flavoring agent is the daily dose of 0.25-1 mg. To activate the effect of the drug taking pills on an empty stomach. Do not forget to drink the medicine with water. With such a reception Anastrozole quickly enters the bloodstream from the gastrointestinal tract. Remember – the duration of the use of anastrozole description in any case should not exceed 2 weeks. Do not take the drug to women. Anastrozole contributes to the rapid hormonal changes, which is highly undesirable for the body athletes.
Most of the reviews on this drug are positive. Most often this applies to those bodybuilders who follow the correct dosage. It is very good to use anastrozole in bodybuilding, it helps in the prevention of gynecomastia, and many men have been cured of this disease in the initial stages.
The medication perfectly helps women who are in the postmenopausal period, also it effectively fights against cancerous tumors in the chest. Many women after taking this drug noticed a positive dynamics and improvement of well-being.
Anastrozole is contraindicated if you have cardiovascular disease. The drug suppresses the production of good cholesterol. Athletes with SSS disease before taking the drug should consult with a doctor.